Senior/Principal Scientist – Therapeutic Discovery (Protein Engineering)

3T Biosciences is solving a major bottleneck in the field of immunotherapy – identifying novel targets that can be used to generate therapies to treat cancer in broad patient populations. We are developing transformative T cell receptor therapies for cancer and other immune-related diseases. Our proprietary experimental and computational technology allows us to identify novel T cell receptor targets as well as clinical toxicities to bring safe and effective therapies.


We’re committed to making a difference for patients. Our focused, creative, and ambitious team makes 3T Biosciences the perfect engine to drive therapeutic solutions to reality. We’re looking for enthusiastic and self-motivated individuals to bring their talents to a fast-paced environment.

Your Typical Responsibilities:

  • Design and construct antibody libraries
  • Design, execute and manage antibody discovery campaigns
  • Lead and execute antibody discovery selections through phage and yeast display
  • Lead and execute antibody screening and characterization through methods such as ELISA, binding kinetics by SPR, flow cytometry and cell-based assays
  • Molecular cloning of library sequences for recombinant expression
  • Explore and implement new technologies in antibody engineering
  • Work in a matrixed team environment, routinely collaborating with Protein Science and Biology groups to advance programs

Required Qualifications:

  • Doctoral (PhD) degree or equivalent or equivalent industry experience
  • Experience with phage and/or yeast-display
  • Experience in designing and generating libraries such as site saturation and combinatorial variant libraries for protein optimization
  • Experience with structural and sequence analysis tools to guide the design of drug candidates
  • Experience in molecular biology including in techniques for DNA construction such as Gibson Assembly
  • Able to manage high throughput scientific workflows
  • Ability to work independently to design, execute, interpret, and troubleshoot experiments
  • Highly organized, experience with ELN documentation.
  • A team player with excellent verbal and written communication skills, ability to thrive in a fast-paced environment among a growing team

Preferred Qualifications:

  • 3+ years of industry experience relevant to protein engineering and protein expression
  • Experience using NGS technologies to address biological questions
  • Development of HT molecular cloning protocols
  • Knowledge of pHLA targets, TCRs, or TCRm
  • Experience working with bi-specifics and cell engagers

Bachelor’s degree or equivalent in relevant fieldPlease contact [email protected] with your cover letter and resume and reference Req# 400-08.

3T Biosciences is an equal opportunity employer. We proudly celebrate diversity and are dedicated to inclusivity.

3T Biosciences does not accept profiles, candidate summaries, or resumes from recruiting vendors without a binding written agreement. Any unsolicited submission of services and or resumes in no way creates an obligation or duty by 3T Biosciences, implied or otherwise.

The anticipated salary range for fully qualified candidates applying for this role at 3T Biosciences California based location will be $130,000 – $190,000 (which may or may not include bonus, equity, or benefits). The final salary offered will be dependent on several factors that include and are not limited to relevant previous experience, job responsibilities and duration of experience, the type and length of experience within the industry and education.

Vaccine Mandate
Employees working in this position will be required to be fully vaccinated against the COVID-19 virus. An applicant is considered fully vaccinated two weeks after their second dose in a 2-dose series, such s the Pfizer or Moderna vaccines or two weeks after a single-dose vaccine, such as Johnson & Johnson’s Janssen vaccine. Applicants will be required to show proof of vaccination status upon receipt of a conditional offer of employment. Any offer of employment will be conditional upon, among other things, an Applicant’s ability to show proof of vaccination status.