Position Specifics:

We are seeking a highly skilled and motivated Scientist/ to join our in vivo pharmacology group. This role will plan, implement, and analyze in vivo immuno-oncology studies to support preclinical discovery and development of novel TCR targeting molecules, from initial screening of lead candidates through preclinical proof-of-concept and on to IND enabling activities. This is an outstanding opportunity to work in a highly productive and collaborative environment and contribute to a diverse panel of therapeutic indications. You will also work in multi-disciplinary collaborations with CROs and academic collaborators, involving a high level of teamwork.

Responsibilities 

  • Duties include planning, execution and analysis of in vivo experiments, management of work within the in vivo pharmacology team, and management of projects at CROs. 
  • Collaborate on multiple projects simultaneously and work closely with scientists from cross-functional disciplines to design studies and meet project deliverables in a timely manner
  • Design of tumor organoid pharmacology studies to test therapeutic compounds for antitumor activities in collaboration with academic collaborators or CROs 
  • Accurate, timely record keeping and data analysis, analyze and interpret data 
  • Generate IACUC protocols when required for new procedures 
  • In vivo work to include handling techniques, such as model development, tumor inoculation 

and measurement, sc and iv dosing, blood, tissue collection and primary cell isolation 

  • Plan and supervise cyno PK studies with therapeutic compounds to support clinical dose finding studies with CROs.
  • Identification and validation of cancer indications and contexts dependent on our drug targets to assist the clinical development of our programs 
  • Contribute to scientific manuscripts, patent applications, and regulatory documents 
  • Prepare and clearly present summaries of results at internal and external meetings.
  • Mentor and/or manage team members, as necessary, in design and execution of experimental work to support team goals.
  • Maintain a working knowledge of projects and understanding of relevant literature to conduct experimental work.

Requirements 

  • Ph.D. in Life Sciences or equivalent training with 5-8 years of industry experience 
  • A strong background in immunology, tumor immunology and T cell biology is preferred
  • Mammalian tissue culture techniques for cell lines and primary cells
  • Expertise using biologics in preclinical oncology models, specifically immune reconstituted models, including design and execution of xenograft tumor studies, rodent handling, tumor measurements, drug administration, tissue processing, 
  • Experience with PK/PD and translational studies and a working understanding of the tumor microenvironment in xenograft tumor models. 
  • Proficiency in analytical techniques including multicolor flow cytometry, ELISA and other immunoassays, cytotoxicity and proliferation assays, and gene expression analysis. 
  • Experience in the phenotypic and functional characterization of immune cell populations in tumors and other organs. 
  • Experience with testing cell therapies and/or monitoring primate studies desirable
  • Excellent problem-solving, analytical and multi-tasking skills to manage competing priorities or projects and meet deadlines 
  • Ability to function independently in a fast-paced work environment and work closely in cross-functional teams to support multiple pre-clinical stage programs 
  • Ability to clearly and efficiently document, communicate and present complex data sets

Please contact info@3tbiosciences.com with your cover letter and resume.