We are seeking a highly skilled and motivated Scientist/ to join our in vivo pharmacology group. This role will plan, implement, and analyze in vivo immuno-oncology studies to support preclinical discovery and development of novel TCR targeting molecules, from initial screening of lead candidates through preclinical proof-of-concept and on to IND enabling activities. This is an outstanding opportunity to work in a highly productive and collaborative environment and contribute to a diverse panel of therapeutic indications. You will also work in multi-disciplinary collaborations with CROs and academic collaborators, involving a high level of teamwork.
- Duties include planning, execution and analysis of in vivo experiments, management of work within the in vivo pharmacology team, and management of projects at CROs.
- Collaborate on multiple projects simultaneously and work closely with scientists from cross-functional disciplines to design studies and meet project deliverables in a timely manner
- Design of tumor organoid pharmacology studies to test therapeutic compounds for antitumor activities in collaboration with academic collaborators or CROs
- Accurate, timely record keeping and data analysis, analyze and interpret data
- Generate IACUC protocols when required for new procedures
- In vivo work to include handling techniques, such as model development, tumor inoculation
and measurement, sc and iv dosing, blood, tissue collection and primary cell isolation
- Plan and supervise cyno PK studies with therapeutic compounds to support clinical dose finding studies with CROs.
- Identification and validation of cancer indications and contexts dependent on our drug targets to assist the clinical development of our programs
- Contribute to scientific manuscripts, patent applications, and regulatory documents
- Prepare and clearly present summaries of results at internal and external meetings.
- Mentor and/or manage team members, as necessary, in design and execution of experimental work to support team goals.
- Maintain a working knowledge of projects and understanding of relevant literature to conduct experimental work.
- Ph.D. in Life Sciences or equivalent training with 5-8 years of industry experience
- A strong background in immunology, tumor immunology and T cell biology is preferred
- Mammalian tissue culture techniques for cell lines and primary cells
- Expertise using biologics in preclinical oncology models, specifically immune reconstituted models, including design and execution of xenograft tumor studies, rodent handling, tumor measurements, drug administration, tissue processing,
- Experience with PK/PD and translational studies and a working understanding of the tumor microenvironment in xenograft tumor models.
- Proficiency in analytical techniques including multicolor flow cytometry, ELISA and other immunoassays, cytotoxicity and proliferation assays, and gene expression analysis.
- Experience in the phenotypic and functional characterization of immune cell populations in tumors and other organs.
- Experience with testing cell therapies and/or monitoring primate studies desirable
- Excellent problem-solving, analytical and multi-tasking skills to manage competing priorities or projects and meet deadlines
- Ability to function independently in a fast-paced work environment and work closely in cross-functional teams to support multiple pre-clinical stage programs
- Ability to clearly and efficiently document, communicate and present complex data sets