The Scientist will be a key contributor to the development and execution of ongoing drug discovery projects. You will primarily be responsible for the development of immunological assays for preclinical discovery and development of novel TCR targeting molecules, from discovery through lead optimization and clinical candidate selection. The position will involve hands-on experimental cellular and molecular immunology and will require knowledge and experience to design and execute experiments in the laboratory setting. You will also work in multi-disciplinary collaborations with CROs and academic collaborators, involving a high level of teamwork.
- Develop, validate, and execute biochemical and screening assays to identify and characterize drug candidates in our pipeline
- Use expertise to design, execute, and interpret data from experiments to support evaluation of biologic candidate ID and validation.
- Design in vitro safety experiments with therapeutic compounds in the context of human iPSC cell lines, immortalized human primary cells or normal cells grown in vitro, to study potential normal tissue toxicity of biologics of adoptive cell therapies on normal tissues.
- Use technical ability and expertise to execute and troubleshoot flow cytometry, live cell imaging and MSD-based assays.
- Prepare and clearly present summaries of results and ideas at internal and external meetings.
- Mentor and/or manage team members, as necessary, in design and execution of experimental work to support team goals.
- Maintain a working knowledge of projects and understanding of relevant literature to conduct experimental work.
- Contribute to the drafting of scientific manuscripts, patent applications, and regulatory documents
- Work closely with our multi-disciplinary team of scientists, and interact with external CRO partners to generate novel hypotheses and advance our scientific priorities
- Maintain up to date knowledge of advancements in the field and new laboratory techniques and technologies
- Organize and present experimental results at regular internal meetings
- Maintain accurate, well-organized experimental records
- Ph.D. in Life Sciences or equivalent training with 5-8 years of industry experience
- Excellent technical cell and molecular biology skills (e.g. FACS, imaging, viability assays, reporter assays, etc) with ability to apply these skills to cell-based assay development
- Experience with mammalian cell culture required, experience with organoid cultures a plus
- Familiarity with T cell biology, tumor immunology and cancer immunotherapy
- Extensive experience with flow cytometry and cell-based assays for immune cells, including cytotoxicity assays, proliferation, and cytokine/chemokine measurements
- Experience with in vitro characterization of biologic drugs in an industry setting, required
- Excellent problem-solving, analytical and multi-tasking skills to manage competing priorities or projects and meet deadlines
- Ability to function independently in a fast-paced work environment and work closely in cross-functional teams to support multiple pre-clinical stage programs
- Ability to clearly and efficiently document, communicate and present complex data sets